Other fewer regularly noticed adverse reactions envisioned from opioid analgesics, together with codeine sulfate, involve:

Acute or serious bronchial asthma within an unmonitored location or in absence of resuscitative tools. (4)

Codeine sulfate is contraindicated in patients with respiratory depression in the absence of resuscitative devices.

INDICATIONS AND use Codeine Sulfate Tablets are an opioid agonist, indicated for the management of gentle to average discomfort, in which read more treatment using an opioid is acceptable and for which alternative solutions are insufficient. (1)

In scientific tests in rats, doses with the one hundred twenty mg/kg level (oral; around three situations the maximum proposed each day dose of 360 mg/working day for Grownups on the mg/m2 basis) through organogenesis, inside the poisonous assortment to the Grownup animal, were being related to a rise in embryo resorption at enough time of implantation.

more help and checking may very well be required when prescribing for patients at risk of opioid misuse.

Anti-arrhythmics: codeine delays the absorption of mexiletine. The analgesic exercise of codeine is likely to be appreciably impaired by quinidine which impairs codeine metabolism.

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following halting use of a CYP2D6 inhibitor, take into account lowering the Codeine Sulfate Tablets dosage and Examine the individual at Regular intervals for indications and indications of respiratory depression or sedation [see Drug Interactions (7)].

In case you have been taking Codeine Sulfate Tablets often, never quit using codeine sulfate without the need of talking to your healthcare provider.

Plasma 50 %-life of codeine and its metabolites are actually described to become around three several hours Label.

Codeine sulfate really should be Utilized in warning in clients with biliary tract disease, such as acute pancreatitis, as codeine sulfate may well cause spasm from the sphincter of Oddi and diminish biliary and pancreatic secretions.

Reserve concomitant prescribing of those drugs to be used in patients for whom substitute cure alternatives are inadequate. Limit dosages and durations on the minimal demanded. tell clients and caregivers of this prospective conversation and teach them around the symptoms and signs of respiratory despair (including sedation).

three)], which could maximize or prolong the two the therapeutic consequences and adverse reactions, and should lead to severe respiratory depression.